Research article2024Peer reviewed
Clinical significance of the TK1 specific activity in the early detection of ovarian cancer
Osredkar, Josko; Jagarlamudi, Kiran Kumar; Cviic, Diana et al.
Staffan Eriksson
Department of Animal Biosciences
Faculty of Veterinary Medicine and Animal Sciences
Email: Staffan.Eriksson@slu.se
Publications
Research article2023Peer reviewedOpen access
A Dual Biomarker TK1 Protein and CA125 or HE4-Based Algorithm as a Better Diagnostic Tool than ROMA Index in Early Detection of Ovarian Cancer
Cviic, Diana; Jagarlamudi, Kiran; Meglic, Leon et al.
Research article2023Peer reviewedOpen access
A monoclonal antibody-based sandwich ELISA for measuring canine Thymidine kinase 1 protein and its role as biomarker in canine lymphoma
Sharif, Hanan; Saellstrom, Sara; Kolli, Bhavya et al.
Research article2022Peer reviewedOpen access
Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase
Frisk, Junmei Hu; Pejler, Gunnar; Eriksson, Staffan et al.
Research article2022Peer reviewedOpen access
Analytical and clinical characterization of an optimized dual monoclonal sandwich ELISA for the quantification of thymidine kinase 1 (TK1) protein in human blood samples
Jagarlamudi, K. K.; Swinkels, L.; Zupan, M. et al.
Research article2022Peer reviewedOpen access
Serum TK1 protein and C-reactive protein correlate to treatment response and predict survival in dogs with hematologic malignancies
Saellstrom, S.; Sharif, H.; Jagarlamudi, K. K. et al.
Research article2022Peer reviewedOpen access
Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders
Frisk, Junmei Hu; Orn, Stefan; Pejler, Gunnar et al.
Research article2022Peer reviewedOpen access
Mutational analyses of human thymidine kinase 2 reveal key residues in ATP-Mg2+ binding and catalysis
Wang, Liya; Eriksson, Staffan.
Research article2022Peer reviewedOpen access
Structural and functional analysis of human thymidylate kinase isoforms
Frisk, Jun Mei Hu; Pejler, Gunnar; Eriksson, Staffan et al.
Research article2021Peer reviewedOpen access
Blood biomarker algorithms for the diagnosis of mycoplasma pneumoniae respiratory infections
Venge, Per; Eriksson, Staffan; Pauksen, Karlis.
Research article2021Peer reviewedOpen access
Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma
Ulfstedt, Johan Mattsson; Venge, Per; Holmgren, Sofia et al.
Research article2021Peer reviewedOpen access
Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity
Frisk, Jun Mei Hu; Vanoevelen, J. M.; Bierau, Jörgen et al.
Research article2021Peer reviewedOpen access
Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma
Wang, Liya; Unger, Lucia; Sharif, Hanan et al.
Research article2021Peer reviewedOpen access
Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker
Wang, Liya; Sharif, Hanan; Saellstrom, Sara et al.
Research article2020Peer reviewedOpen access
AroCell TK 210 ELISA for determination of TK1 protein: age-related reference ranges and comparison with other TK1 assays
Kumar, Jagarlamudi Kiran; Holmgren, Sofia; Levedahl, Kerstin Hamberg et al.
Research article2020Peer reviewed
Identification of a novel thymidylate kinase activity
Frisk, Junmei Hu; Eriksson, Staffan; Pejler, Gunnar et al.
Research article2020Peer reviewedOpen access
Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency
Wang, Liya; Sun, Ren; Eriksson, Staffan.
Research article2020Peer reviewed
The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs
Sun, Ren; Eriksson, Staffan; Wang, Liya.
Research article2019Peer reviewed
The combination of AroCell TK 210 ELISA with Prostate Health Index or prostate-specific antigen density can improve the ability to differentiate prostate cancer from noncancerous conditions
Jagarlamudi, Kiran Kumar; Zupan, Mojca; Kumer, Kristina et al.
Research article2018Peer reviewedOpen access
Negative Cooperative Binding of Thymidine, Ordered Substrate Binding, and Product Release of Human Mitochondrial Thymidine Kinase 2 Explain Its Complex Kinetic Properties and Physiological Functions
Wang, Liya; Zhang, Li; Sun, Ren et al.
Research article2018Peer reviewed
Doxorubicin effects on leukemia and breast cancer cells in culture on the TK1 protein levels using AroCell TK 210 ELISA: a tool for drug development
Jagarlamudi, K. K.; Wang, L.; Eriksson, S..
Research article2017Peer reviewedOpen access
Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker
Wang, Jianjun; Liu, Qi; Zhou, Xiaodie et al.
Research article2016Peer reviewedOpen access
A clinical evaluation of the TK 210 ELISA in sera from breast cancer patients demonstrates high sensitivity and specificity in all stages of disease
Kumar, J. Kiran; Aronsson, A. C.; Pilko, G. et al.
Research article2015Peer reviewedOpen access
Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker
Jagarlamudi, Kiran Kumar; Hansson, Lars Olof; Eriksson, Staffan.
Research article2015Peer reviewed
Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells
Sjuvarsson, Elena; Marquez, Victor E; Eriksson, Staffan.
Review article2015Peer reviewedOpen access
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
Goodson III, William H; Eriksson, Staffan; Hultman, Tove et al.
Research article2015Peer reviewedOpen access
A New Sandwich ELISA for Quantification of Thymidine Kinase 1 Protein Levels in Sera from Dogs with Different Malignancies Can Aid in Disease Management : Dog TK1-ELISA
Jagarlamudi, Kiran Kumar; Moreau, Laura; Westberg, Sara et al.
Review article2015Peer reviewedOpen access
The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling
Engström, Wilhelm; Eriksson, Staffan; Bisson, William H.
Research article2014Peer reviewed
Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: Implication for mitochondrial toxicities of anti-HIV nucleoside analogs
Sun, Ren; Eriksson, Staffan; Wang, Liya.
Research article2014Peer reviewed
Mitochondrial thymidine kinase 2 but not deoxyguanosine kinase is up-regulated during the stationary growth phase of cultured cells
Sun, Ren; Eriksson, Staffan; Wang, Liya.
Research article2014Peer reviewedOpen access
Zidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs
Sun, Ren; Eriksson, Staffan; Wang, Liya.
Research article2014Peer reviewedOpen access
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker
Jagarlamudi KK, Westberg S, Ronnberg H, Eriksson S.
Research article2014Peer reviewed
Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung
Xu, Yan; Liu, Biao; Shi, Qun-Li et al.
Conference abstract2014
The new TK 201 ELISA provides prognostic information in patients with breast cancer
Kumar, K. J.; Aronsson, A. C.; Pilko, G. et al.
Research article2013Peer reviewed
Elevation of serum thymidine kinase 1 in a bacterial infection: Canine pyometra
Sharif, Hanan; Hagman, Ragnvi; Wang, Liya et al.
Research article2013Peer reviewedOpen access
Synthesis of N3-substituted carboranyl thymidine bioconjugates and their evaluation as substrates of recombinant human thymidine kinase 1
Agarwal, Hitech K.; McElroy, Craig, A.; Sjuvarsson, Elena et al.
Research article2013Peer reviewed
Homogeneous assay for real-time and simultaneous detection of thymidine kinase 1 and deoxycytidine kinase activities
Stålhandske, Per; Wang, Liya; Westberg, Sara et al.
Research article2013Peer reviewed
Is the Expression of Deoxynucleoside Kinases and 5 '-nucleotidases in Animal Tissues Related to the Biological Effects of Nucleoside Analogs?
Eriksson, Staffan.
Research article2013Peer reviewedOpen access
Cellular Influx, Efflux, and Anabolism of 3-Carboranyl Thymidine Analogs: Potential Boron Delivery Agents for Neutron Capture Therapy
Sjuvarsson, Elena; Damaraju, Vijaya L.; Mowles, Delores et al.
Research article2013Peer reviewed
PHOSPHORYLATION OF NUCLEOSIDE-METALLACARBORANE AND CARBORANE CONJUGATES BY NUCLEOSIDE KINASES
Wang, Liya; Wojtczak, Blazej A.; Olejniczak, Agnieszka B. et al.
Research article2013Peer reviewed
High levels of inactive thymidine kinase 1 polypeptide detected in sera from dogs with solid tumours by immunoaffinity methods: Implications for in vitro diagnostics
Jagarlamudi, Kiran Kumar; Sharif, Hanan; Westberg, Sara et al.
Research article2012Peer reviewedOpen access
Oxidative Stress Induced S-glutathionylation and Proteolytic Degradation of Mitochondrial Thymidine Kinase 2
Sun, Ren; Eriksson, Staffan; Wang, Liya.
Research article2012Peer reviewed
A sensitive and kinetically defined radiochemical assay for canine and human serum thymidine kinase 1 (TK1) to monitor canine malignant lymphoma
Sharif, Hanan; Von Euler, Henrik; Westberg, Sara et al.
Research article2012Peer reviewed
High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma
Xu, Yan; Shi, Qun-LI; Ma, Henghui et al.
Research article2012Peer reviewedOpen access
Quaternary Structures of Recombinant, Cellular and Serum Forms of Thymidine Kinase 1 from Dogs and Humans
Sharif, Hanan; Jagarlamudi, Kiran Kumar; Wang, Liya et al.
Conference abstract2012Peer reviewed
The increase in serum thymidine kinase 1 subunit levels is more significant than the TK1-activities in samples from patients with solid tumors; implications for disease detection and monitoring efficiency
Jagarlamudi, K-K; Sharif, H.; von Euler, S. H. et al.
Research article2012Peer reviewedOpen access
Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism
Egeblad, Louise; Welin, M; Flodin, S et al.
Research article2012Peer reviewed
Biochemistry and biology of 2’-fluoro-2’-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2)
Wiebe, LI; Sun, W; Zhou, A et al.
Research article2011Peer reviewedOpen access
The Kinetic Effects on Thymidine Kinase 2 by Enzyme-Bound dTTP May Explain the Mitochondrial Side Effects of Antiviral Thymidine Analogs
Wang, Liya; Sun, Ren; Eriksson, Staffan.
Research article2011Peer reviewedOpen access
Comparative aspects of the proliferation marker thymidine kinase 1 in human and canine tumour diseases
von Euler Henrik, Eriksson Staffan.
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